The transcriptional program, functional heterogeneity, and clinical targeting of mast cells
نویسندگان
چکیده
منابع مشابه
The transcriptional program, functional heterogeneity, and clinical targeting of mast cells
Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen-immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extraordinary ability to respond rapidly by releasing granule-stored and newly mad...
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Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible relationship between increased number of mast cells and clinical and histological p...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2017
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.20170910